International Review of Ophthalmology

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Research status of transsynaptic retrograde degenerating optic neuropathy

MAO Jun-feng1, WEI Shi-hui2   

  1. 1Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China; 2Department of Ophthalmology, The General Hospital of the People’s Liberation Army, Beijing 100853, China
  • Received:2016-09-27 Online:2016-12-22 Published:2016-12-21
  • Contact: MAO Jun-feng, Email: mao_junfeng@163.com

Abstract:

Transsynaptic retrograde degeneration of retinal ganglion cells was induced by a lesion in the lateral geniculate nucleus, and/or the visual cortex of occipital lobe. This optic neuropathy is referred to as transsynaptic retrograde degenerating optic neuropathy, and its pathological basis is the apoptosis of P beta retinal ganglion cells.The degenerating extent depends on the age at which visual cortex was damaged, the survival time,the size of the cortical lesion,the binocular interactions and the species.(Int Rev Ophthalmol, 2016, 40: 405-408)